The hazard ratios of POS stage Ⅰ, Ⅱ, and Ⅲ were 1.00, 2.25, and 4.99, respectively. We judged model 4 to be a superior POS staging system it defined SpO 2 ≥ 96% at rest without desaturation as stage Ⅰ SpO 2 ≥ 96% at rest with desaturation or SpO 2 90%-95% at rest without desaturation as stage Ⅱ and SpO 2 90%-95% at rest with desaturation or SpO 2 < 90% at rest as stage Ⅲ. Two-hundred and nineteen IPF patients were studied and the C-statistic values of models 1, 2, 3, and 4 were 0.633, 0.643, 0.630, and 0.673, respectively. The cutoff SpO 2 values at rest were 96% and 90%, and desaturation was defined as SpO 2 < 90% at the end of the 6-min-walk test. We developed four prototype staging systems based on SpO 2 at rest and desaturation, and adopted the system with the highest C-statistic as the POS staging system. We propose a pulse oximetry saturation (POS) staging system consisting of SpO 2 parameters to predict prognosis. ![]() Recently, noninvasive and simple measurements of oxygen saturation by pulse oximetry (SpO 2) have been used for severity assessments. ![]() However, this system requires invasive procedures to measure arterial oxygen tension. ![]() In Japan, the severity staging system for idiopathic pulmonary fibrosis (IPF) has been used to determine medical care subsidies.
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